Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Fentanyl injection can be injected into muscle intramuscular or into veins intravenous. Emergency overview fentanyl citrate injection is a solution containing fentanyl citrate, a potent narcotic analgesic. Dosage should be reduced in elderly or debilitated patients see precautions. Consult individual prescribing information naloxone before employing. The name of your medicine is fentanyl 50 microgramsml solution for injectioninfusion. Furthermore, the update also takes into account the new legal requirements which have come into force since the previous revision. As an opioid, fentanyl citrate injection exposes users to the risks of addiction, abuse, and misuse see drug abuse and dependence 9. Fentanyl citrate injection contains fentanyl, a schedule cii controlled substance. Because it is a strong opioid narcotic, you should not use fentanyl for shortterm pain, including headaches or migraines. Transdermal and parenteral fentanyl dosage calculations and conversions objectives after reading this chapter and completing all practice problems, the participant will be able to.
Fentanyl citrate injection is used in the treatment of moderatetosevere pain. Fentanyl belongs to the group of medicines called narcotic analgesics pain medicines. Potential adverse reactions from prescribed doses and overdoses are described in the package insert. It can be used for both longterm or breakthrough pain control. What you need to know before you are given fentanyl injectioninfusion 3. Iv fentanyl administration is a shared competency and may be administered by a physician or a registered nurse certified in this procedure. It acts in the central nervous system cns or brain to relieve pain.
Package inserts in fentanyl citrate lollipops or other forms of this medication list guidelines for using, storing and handling this medication. Read all of this leaflet carefully before you start using this medicine because it contains. If prolonged opioid use is required in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Fentanyl citrate solution for injection drug summary. Fentanyl is also used as a recreational drug, often mixed with heroin or cocaine. Fentanyl novaplus patch fda prescribing information. Fentanyl injection is an analgesic opioid that is fda approved for the treatment of general or regional anesthesia. Fentanyl is an ingredient found in many different prescription pain medications.
Fentanyl transdermal system duragesic 12 mcghr25 mcghr375. If fentanyl is administered with neuroleptics, the user should be familiar with the special properties of each drug, particularly with regard to durations of action. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Fentanyl solution for injection details of the supplier of the safety data sheet. Oct 09, 2019 fentanyl citrate injection contains fentanyl, a schedule ii controlled substance. Store at 20 to 25c 68 to 77f see usp controlled room temperature. Sufentanil citrate injection is a sterile, preservative free, aqueous solution containing sufentanil citrate equivalent to 50 mcg per ml of sufentanil base for intravenous and epidural injection. Find patient medical information for fentanyl pf injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Serious or lifethreatening breathing problems that can lead to death can. Fentanyl citrate is chemically identified as n1phenethyl4piperidyl propionanilide citrate 1. I have fentanyl patches, sandoz brand, which are matrix not gel. It is prescribed in the event of chronic, severe pain as a result of cancer, nerve damage, back injury, major trauma. Full text injection devicerelated risk management toward.
Oral transmucosal fentanyl citrate for premedication in. The injection may be given into a vein or into a muscle. Fentanyl citrate injection is an opioid agonist, available as a sterile, nonpyrogenic solution containing fentanyl citrate equivalent to 50 mcg 0. The usual dose for surgical premedication in adults is 0.
Describe the pharmacokinetics of transdermal fentanyl, and variables that can influence dosing. Do not breastfeed or use breast milk that has been expressed for 24 hours after having fentanyl injection. The most characteristic effect of intravenous etomidate on the respiratory system is a slight elevation in. In higher doses, fentanyl injection is used to provide pain relief in patients. In studies transdermal or intravenous fentanyl was used and in 6 studies oromucosal fentanyl was. Fentanyl 100 micrograms in 2ml solution for injection.
It will be referred to as fentanyl injection infusion for ease hereafter. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for duragesic fentanyl. Clinically, fentanyl citrate is indicated as an analgesic to supplement general or regional anesthesia. It has a rapid onset and its effects generally last less than two hours. Fentanyl by injection national library of medicine. Fentanyl is the generic form of the brandname drug duragesic, a prescription opioid narcotic drug used to treat chronic, aroundtheclock pain. Fentanyl citrate injection, usp is a sterile, nonpyrogenic, preservative free aqueous solution for intravenous or intramuscular injection. Fentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of nphenyl1 2phenylethylpiperidin4amine with propanoic acid. Overdose the doctor or nurse giving you fentanyl will be experienced in its use, so it is extremely unlikely that you will be given too much. Noxafil injection should be avoided in patients with moderate or severe renal impairment creatinine clearance injection.
Cmdh scientific conclusions and grounds for the variation. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for duragesic fentanyl skip to. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to overdose or death. Fentanyl injection is used to relieve severe pain during and after surgery. The finished product specifications are adequate to control the relevant parameters for the dosage form. Fentanyl transdermal system is a transdermal formulation of fentanyl indicated for the management of persistent, moderate to severe chronic pain in opioidtolerant patients 2 years of age and older when a continuous, aroundtheclock opioid analgesic is required for an extended period of time, and the patient cannot be managed by other means such. Repeated administration at short term intervals for prolonged periods. It will be referred to as fentanyl injectioninfusion for ease hereafter. Sublimaze injection contains fentanyl 50 micrograms per ml as fentanyl citrate. Aug 21, 2012 add sufficient sterile water for injection to final volume and mix well. Inhalation, ingestion, eye contact, skin absorption.
Fentanyl, also spelled fentanil, is an opioid used as a pain medication and together with other medications for anesthesia. Transdermal and parenteral fentanyl dosage calculations and. Dose may be calculated using dose conversion guidelines in the product package insert, local protocol, or another reliable reference. Prolonged use of morphine sulfate injection during pregnancy can threatening if not recognized and treated. Which is 420mg of morphine total equivalent to my normal shot. Fentanyl injection fda prescribing information, side. Fentanyl citrate injection contains fentanyl, a schedule ii controlled substance. Intravenous fentanyl may only be administered by an rn who has current cardio.
The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication. Find out what health conditions may be a health risk when taken with fentanyl pf injection. It is also used with other medicines just before or during an operation to help the anesthetic work better. What you need to know before you are given fentanyl injection infusion 3. Otfc group n 30, placebo group n 30, and control group n 30. Fentanyl is a strong, synthetic manmade narcotic that is similar to morphine. Noxafil injection should be avoided in patients with moderate or severe renal impairment creatinine clearance usp is a sterile, nonpyrogenic, preservative free aqueous solution for intravenous or intramuscular injection. Appropriat e educati on and inser vicing r egarding t he administ rati on of fentanyl is a facilityspecific responsibility.
Patients were randomly assigned to one of three groups. Add sufficient sterile water for injection to final volume and mix well. Webmd provides common contraindications for fentanyl pf injection. Mylan manufactures fentanyl transdermal system duragesic in strengths of 12 mcghr25 mcghr375 mcghr50 mcghr625 mcghr75 mcghr875 mcghr100 mcghr. Injection devicerelated risk management toward safe administration of medications. For example, the package insert now includes information on the benefits of themedicine, itsusein children and a reorganised side effect section 10. The educational content on wikidoc drug pages is based upon the fda package insert, national library of medicine content and practice guidelines consensus statements. Fentanyl stimulates receptors on nerves in the brain to increase the threshold to pain the amount of stimulation it takes to feel pain and reduce the perception of pain the perceived. Fentanyl actiq side effects, dosage, interactions drugs. Fentanyl citrate injection, usp r x only description fentanyl citrate is a potent narcotic analgesic. What fentanyl injection infusion is and what it is used for 2.
Airborne dusts are irritating to the eyes with symptoms of burning, redness, tearing and pain. As an opioid, fentanyl citrate injection exposes users to the risks of addiction, abuse, and misuse see drug abuse and dependence. Duragesic label page 1 full prescribing information for use. Fentanyl injection bp fentanyl citrate drug medicine. Recommend an appropriate dose of transdermal fentanyl when. Arterial blood pressure, heart rate, respiratory frequency. Fentanyl novaplus patch fda prescribing information, side. Following duragesic application, the skin under the system absorbs fentanyl, and a depot of fentanyl concentrates in the upper skin layers. Apr 21, 2020 the duration of fentanyl transdermal system use varied in cancer patients.
Although a fentanyl citrate msds is typically used by healthcare professionals and chemists, patients can access this information when researching the drug. What fentanyl injectioninfusion is and what it is used for 2. Fentanyl is part of a group of drugs known as opioids. Each milliliter of solution contains fentanyl as the citrate 50 mcg 0. Do not drive or use any tools or machines for at least 24 hours after having fentanyl injection. Apr 10, 2020 dose may be calculated using dose conversion guidelines in the product package insert, local protocol, or another reliable reference. Oral transmucosal fentanyl citrate for premedication in adul. Some fentanyl products are used aroundtheclock to treat persistent, chronic pain, while others are used on an asneeded basis for breakthrough pain. The effects of otfc, placebo oralet, and no premedication were compared in a prospective, doubleblind study on 90 adult asa physical status i and ii patients undergoing sameday admission surgery. In the us, fentanyl citrate is a schedule cii narcotic and has the potential for abuse. Fentanyl citrate injection is a sterile, nonpyrogenic, preservative free aqueous solution for intravenous or intramuscular injection. Duragesic is a longacting extendedrelease opioid pain medicine narcotic that can put you at risk for overdose and death. Opioids interact with opioid receptors in the brain and elicit a range of responses within the body. Transdermal and parenteral fentanyl dosage calculations.